Mainstream blogs are more acceptable and accessible everywhere, so you could sink in a sea of otherblogs unless your SEO is very SE scrumptious...
Or you could check out the competition and see how they rank on the SEO and the SERPs level...
I like seeing that "the other guy" is weaker than me on the optimization level, and basically make the next-highest my target, and do tracking crackdowns for a little while (obsessively check stats :P ).
Just to keep being long-winded...
I think it's easier for mainstream, though, since so much of mainstream isn't so much about quality but quanity, getting ripped off on impressions-based advertising, and don't forget there's a hell of a lot of crap out there too (both on the bad-site basis and on a bad-SE marketing basis).
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